http://www.pathogenomics-era.net/index.php  
About CDIFFGEN Project Consortium

CDIFFGEN


Pathogenomic of increased Clostridium difficile virulence

 

Clostridium difficile is increasingly associated with infections in hospitals and in the community. Several EU countries and some non EU countries are experiencing emergence of hypervirulent type(s) of C. difficile causing disease with higher mortality, severity and increased relapse rates.

The overall objective of this ERA NET PathoGenoMics project is to use genomic approaches to study C. difficile groups with increased virulence and subsequently analyze their genomic characteristics in terms of the presence of known and new virulence factors, regulation of their expression and genomic heterogeneity.

Hypervirulent type BI/NAP1/027 has gained most attention and is currently detected in sporadic cases or outbreaks in most EU countries. However, several other types are associated with increased virulence, such as ribotype 017 (A-B+ strain) or ribotype 053 which is currently described only in Austria.

One of the aims of proposed project is also to adjust the PCR ribotyping method into an interchangeable format. This will be achieved by exchanging the agarose gel electrophoresis with more precise and repeatable method, capillary gel electrophoresis, and establishment of internet based site for data analysis.

Maja Rupnik
Institute of Public Health Maribor
Centre for Microbiology
Maribor


Bruno Dupuy
Institut Pasteur
Paris


Frederic Barbut
Laboratoire "Clostridium difficile" associé au CNR des Anaérobies


Faculté de Médecine Pierre et
Marie Curie
Paris


Adriano O. Henriques
Instituto de Tecnologia Química e Biológica
Oeiras


Alexander Indra
Austrian Agency for Health and Food Safety
Vienna


Wolfgang Liebl
Technische Universität München
Lehrstuhl für Mikrobiologie
Freising

Phone
+386 2 4500 183
Mail
maja.rupnik@zzv-mb.si
  Powered by